Current Trends in Mass Spectrometry and Chromatography

About Conference

Conference Series LLc Ltd  invites all the participants from all over the world to attend 8th International Conference on Current Trends in Mass Spectrometry and Chromatography' during October 31-November 01, 2018 in Columbus, USA which presents talks and presentation  from highly eminent persons and exhibition of Standard Companies .

Mass Spectrometry 2018 is a best platform to meet and share the knowledge with eminent persons related to academy and towards the industrial knowledge. Mass Spectrometry 2018 conference covers all the fields related to Mass Spectrometry and chromatography. There will be many seminars, workshops and technical sessions take place which will catch the attention of the professionals to attend Mass Spectrometry 2018 conference and it would enormously enrich our knowledge in understanding the current requirements of the global pharmaceutical industry and academic area. The experts will get an excellent opportunity to give many presentations and lectures on different topic and will also present their case studies. 

The main aim of the theme of the conference to enlighten the innovations nad current trends with mass spectrometry and Chromatography. This conference brings together individuals who are interested in fields of mass spectrometry, chromatography and analytical chemistry and approaching towards the conference gives best platform to explore the ideas and axplore the isuues concerned to relevant topic and generate solutions. As per the Frost and Sullivan report analytical market is growing on an average 0.4% annually. This report studies the global mass spectrometry market over the forecast period of 2013 to 2018. The market was estimated at $3.9 billion in 2013 and is expected to reach $5.9 billion by 2018, growing at a CAGR of 8.7% from 2013 to 2018.North America dominated the global mass spectrometry market in 2013, followed by Europe and Asia. The North American market is likely to be driven by factors such as the increasing number of government investments in pharmaceutical, biotechnology, medical, and academic research studies that make use of mass spectrometry techniques. On the other hand, Asia is expected to grow at the highest CAGR due to the presence of high-growth markets such as India and China, the improved funding scenario in this region, increasing number of conferences and exhibitions on mass spectrometry, and increased focus of the giant players in these countries.

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Market Analysis

Mass Spectrometry 2018 welcomes all attendees, presenters, and exhibitors from all over the world to Columbus, Ohio, USA. We are delighted to invite you all to attend and register for the “8th International Conference on Current Trends in Mass Spectrometry and Chromatography” which is going to be held during October 31-November 01, 2018 in Columbus, USA.

The organizing committee is moving on to an exciting and informative conference program including plenary lectures, symposia, workshops on a variety of topics, poster presentations and various programs for participants from all over the world. We invite you to join us at the Mass Spectrometry 2018, where you will be glad to have a meaningful experience with scholars from around the world. All members of the Mass Spectrometry 2018 organizing committee look forward to meeting you in Columbus, USA.

Based on application, the market is segmented into pharmaceuticals, biotechnology, industrial chemistry, environmental testing, food & beverage testing, and others. In 2015, the pharmaceuticals segment is estimated to account for the major share of the mass spectrometry market. On the basis of region, the market is divided into North America, Europe, Asia-Pacific, and the Rest of the World (RoW). In 2015, North America is expected to account for the largest share of the mass spectrometry market, followed by Europe and Asia-Pacific. However, the Asia-Pacific market is slated to grow at the highest CAGR during the forecast period and serve as a revenue pocket for companies offering mass spectrometry equipment.

Some major players in the global mass spectrometry market include Agilent Technologies (U.S.), Danaher Corporation (U.S.), PerkinElmer (U.S.), Thermo Fisher Scientific (U.S.), Bruker Corporation (U.S), Waters Corporation (U.S), Shimadzu Corporation (Japan), Leco Corporation (U.S.), Dani Instruments S.P.A. (Italy), and Kore Technologies, Ltd. (U.K.).

The mass spectrometry community is probably the largest group of scientists working around a single tool.  Mass spectrometry (MS), arguably the most important analytical spectroscopic tool of modern times.  There is no single area of experimental science where mass spectroscopy is not being used. There is no university or research institution in the developed world without a mass spectrometer.

Why Columbus ?

Columbus is one of the largest cities in USA in aspects of economy population education and science research which made it favorite destination for scientific meetings.

The Columbus City is full of beautiful neighborhoods and it is 14^th largest city in USA, It has been rated one of the best city in aspects of business and career. Columbus has many attractive places for sightseeing such as parks and fairs .

Sessions/Tracks

Track 1: New developments in Mass Spectrometry

 

Mass spectrometry (MS) is an analytical technique that ionizes chemical species and separates the ions based on their mass to charge ratio. The new advancements in current trends of using mass spectrometry hold promises to address the shortcomings of data-dependent analysis and selected reaction monitoring (SRM) employed in shotgun and targeted proteomics, respectively the advancements includes all-ion fragmentation, Fourier transform-all reaction monitoring, SWATH Acquisition, multiplexed MS/MS, pseudo-SRM (pSRM) and parallel reaction monitoring (PRM).Mass spectrometry in the analytical technique which  is being used in laboratories by researches and scientist from past 25years

Mass spectrometry has been enhanced with advanced features related the fields in science and medical analysis. Of the various sorts of explanatory methods utilized as a part of drug discovery and advancement, mass spectrometry (MS) has turned out to be a standout amongst the most capable apparatuses for the investigations of an extensive variety of concoction and natural substances. In reality the requests of the pharmaceutical and biotechnology enterprises have driven merchants to some remarkable late advances in mass spectrometry innovation.

 

Track 2: Innovations in Mass Spectrometry techniques

A critical upgrade to the mass settling and mass deciding capacities of mass spectrometry is utilizing it pair with chromatographic and other separation methods. The techniques with combination of gas chromatography-mass Spectrometry LC-MS Capillary electrophoresis–mass spectrometry ion mobility spectrometry-mass spectrometry have been main techniques of separation used in laboratory and academic field.

New mass spectrometry (MS) methods, collectively known as data independent analysis and hyper reaction monitoring, have recently emerged. The analysis of peptides generated by proteolytic digestion of proteins, known as bottom-up proteomics, serves as the basis for many of the protein research undertaken by mass spectrometry (MS) laboratories. Discovery-based or shotgun proteomics employs data-dependent acquisition (DDA). Herein, a hybrid mass spectrometer first performs a survey scan, from which the peptide ions with the intensity above a predefined threshold value, are stochastically selected, isolated and sequenced by product ion scanning. n targeted proteomics, selected environmental Monitoring (ERM), also known as multiple reaction monitoring (MRM), is used to monitor a number of selected precursor-fragment transitions of the targeted amino acids. The selection of the SRM transitions is normally calculated on the basis of the data acquired previously by product ion scanning, repository data in the public databases or based on a series of empirical rules predicting the Enzyme structure sites.

Track 3: Applications in Mass Spectrometry

Application of Mass Spectrometry includes the ion and weights separation. The samples are usually introduced through a heated batch inlet, heated direct insertion probe, or a gas chromatograph. Ionization mass spectrometry (ESI-MS) which has become an increasingly important technique in the clinical laboratory for structural study or quantitative measurement of metabolites in a complex biological sample. MS/MS applications are plentiful, for example in elucidation of structure, determination of fragmentation mechanisms, determination of elementary compositions, applications to high-selectivity and high-sensitivity analysis, observation of ion–molecule reactions and thermochemical  data  determination  (kinetic  method).

Mass spectrometry is an analytical methods with high specificity and a growing presence in laboratory medicine. Various types of mass spectrometers are being used in an increasing number of clinical laboratories around the world, and, as a result, significant improvements in assay performance are occurring rapidly in areas such as toxicology, endocrinology, and biochemical markers. This review serves as a basic introduction to mass spectrometry, its uses, and associated challenges in the clinical laboratory and ends with a brief discussion of newer methods with the greatest potential for Clinical and Diagnostic Research.

Track 4: Mass spectrometry in Proteomics

Mass spectrometry has been widely used to analyze biological samples and has evolved into an indispensable tool for proteomics research. Mass spectrometry is an imperative strategy for the precise mass assurance and portrayal of proteins, and an assortment of strategies and instrumentations have been created for its many employments. Its applications incorporate the recognizable proof of proteins and their post-translational changes, the explanation of protein buildings, their subunits and utilitarian cooperation, and in addition the worldwide estimation of proteins in proteomics. It can likewise be utilized to confine proteins to the different organelles, and decide the collaborations between various proteins and in addition with film lipids. There are two main ways MS is used to identify proteins. Peptide mass fingerprinting uses the masses of proteolytic peptides as input to a search of a database of predicted masses that would arise from digestion of a list of known proteins. If a protein sequence in the reference list gives rise to a significant number of predicted masses that match the experimental values, there is some evidence that this protein was present in the original sample. Purification steps therefore limit the throughput of the peptide mass fingerprinting approach. Peptide mass fingerprinting can be achieved with MS/MS.

Track 5: Applications of Chromatography

Chromatography of many kinds is broadly utilized all through the industrial business. Natural testing research centers search for trace quantities of contaminants such as PCBs in waste oil, and pesticides such as DDT in groundwater. The Environmental Protection Agency utilizes chromatography to test drinking water and to screen air quality. Pharmaceutical organizations utilize chromatography both to get ready expansive amounts of greatly immaculate materials, and furthermore to examine the cleansed mixes for follow contaminants.A developing utilization of chromatography in the pharmaceutical business is for the partition of chiral mixes. These mixes have particles that vary somewhat in the way their molecules are situated in space.

Chromatography is utilized for quality control in the sustenance business, by isolating and breaking down added substances, vitamins, additives, proteins, and amino acids. It can likewise particular and distinguish contaminants, for example, aflatoxin, a disease bringing on compound created by a shape on peanuts. Chromatography can be utilized for purposes as fluctuated as discovering medication mixes in pee or other body liquids, to searching for hints of combustible chemicals in copied material from conceivable incendiarism destinations.

Track 6: Innovations in Chromatography in Science

Analytical technologies and bio/pharmaceutical process improvement have progressed in parallel through need and development.Analytical technologies and bio/pharmaceutical process improvement have progressed in parallel through need and development. Today chromatography is utilized by a wide range of logical controls - and similarly as the method has cultivated advances in examine, the advances have widened and honed the chromatographer's capacities and scope of utilizations. For instance, a restorative physicist who makes another medication must sanitize it from undesirable and perhaps poisonous results that were made in a substance blend. A natural analyst may need to utilize the technique to gauge the levels of perilous chlorohydrocarbons in the tissues of Great Lakes fish to evaluate whether they are ok for human utilization. The various uses of chromatography drive analysts to create frameworks that will isolate blends better, recognize littler measures of material in an example, and do it in a shorter measure of time.

Track 7: Mass Spectrometry Imaging

Mass spectrometry imaging is a technique used in mass spectrometry to visualize the spatial distribution of chemical compositions e.g. compounds, biomarker, metabolites, peptides or proteins by their molecular masses. Although widely used traditional methodologies like radiochemistry and immunohistochemistry achieve the same goal as MSI, they are limited in their abilities to analyze multiple samples at once, and can prove to be lacking if researchers do not have prior knowledge of the samples being studied. Emergency Radiology in the field of MSI are MALDI imaging and secondary ion mass spectrometry imaging (SIMS imaging). Imaging Mass Spectrometry is a technology that combines advanced analytical techniques for the analysis of biomedical Chromatography with spatial fidelity. An effective approach for imaging biological specimens in this way utilizes Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS). Briefly, molecules of interest are embedded in an organic matrix compound that assists in the desorption and ionization of compounds on irradiation with a UV laser. The mass-to-charge ratio of the ions are measured using a Tandem Mass Spectrometry over an ordered array of ablated spots. Multiple analytes are measured simultaneously, capturing a representation or profile of the biological state of the molecules in that sample at a specific location on the tissue surface.

Track 8: Separation Techniques with Mass Spectrometry and Chromatography

Mixtures come in many forms and phases. Most of them can be separated, and the kind of separation method depends on the kind of mixture it is. A separation technique is a strategy to accomplish any marvel that changes over a blend of compound substance into at least two particular item blends, which might be alluded to as blend, no less than one of which is advanced in at least one of the blend's constituents. At times, a partition may completely isolate the blend into its unadulterated constituents. Separation differs in chemical properties or physical properties, for example, measure, shape, mass, thickness, or substance proclivity, between the constituents of a blend. They are frequently arranged by the specific contrasts they use to accomplish division. More often than not there is just physical development and no considerable chemical adjustment. On the off chance that no single contrast can be utilized to finish a coveted detachment, different operations will frequently be performed in blend to accomplish the coveted end.

Track 9: Ionization Techniques

There are many types of ionization techniques are used in mass spectrometry methods. The classic methods that most chemists are familiar with are electron impact (EI) and Fast Atom Bombardment (FAB). These techniques are not used much with modern mass spectrometry except EI for environmental work using GC-MS. Electrospray ionization (ESI) - ESI is the ionization technique that has become the most popular ionization technique. The electrospray is created by putting a high voltage on a flow of liquid at atmospheric pressure, sometimes this is assisted by a concurrent flow of gas. Atmospheric Pressure Chemical Ionization (APCI) - APCI is a method that is typically done using a similar source as ESI, but instead of putting a voltage on the  Electrospray Tandem Mass Spectrometry Newborn Screening itself, the voltage is placed on a needle that creates a corona discharge at atmospheric pressures. Matrix Assisted Laser Electrophoresis is a technique of ionization in which the sample is bombarded with a laser. The sample is typically mixed with a matrix that absorbs the radiation biophysics and transfer a proton to the sample. Gas-Phase Ionization.

Track 10: Troubleshooting, maintenance and experimentation with Mass Spectrometry

Mass spectrometry experiment (MS) is a high-throughput experimental method that characterizes molecules by their mass-to-charge ratio. The MS is composed of sample preparation, molecular ionization, detection, and instrumentation analysis processes. MS is beneficial in that it is generally fast, requires a small amount of sample, and provides high accuracy measurements. For these reasons, MS alone or combined with other structural proteomics techniques is widely used for various molecular biology analysis purposes. Examples of the analysis include post-translations modifications in proteins, identification of vibrational components in proteins, and analysis of protein conformation and dynamics. We will focus on MS-coupled methods that provide information about conformation and dynamics of the protein being studied. For a comprehensive review on MS procedures and for a review on various types of MS-coupled methods.The performance of a mass spectrometer will be severely impaired by the lack of a good vacuum in the ion transfer region of the mass analyser.  As the vacuum deteriorates it will become insufficient to maintain biomedical instrumentation in the operating mode. If the foreline pump is not maintained, the oil may become so contaminated that the  optimum pumping is no longer possible.  Initially, gas transport and metabolism ballasting may clean the oil.  If the  oil has become discoloured then it should be changed according to the pump  manufacturers’ maintenance manual.  When rotary pumps are used to pump away conflict resolution, the solvent can  become dissolved in the oil causing an increase in backing line pressure.  Gas  ballasting is a means of purging the oil to remove dissolved contaminants.

Track 11: Analysis with Mass Spectrometry

With a specific end goal to quantify the attributes of individual particles, a mass spectrometer changes over them to particles so they can be moved about and controlled by outer electric and attractive fields. The three basic elements of a mass spectrometer, and the related parts, are:

1. A little example is ionized, normally to cations by loss of an electron. The Ion Source

2. The particles are arranged and isolated by their mass and charge. The Mass Analyzer

3. The isolated particles are then measured, and the outcomes showed on a graph. The Detector.

Since particles are extremely receptive and fleeting, their arrangement and control must be led in a vacuum. Air weight is around 760 torr (mm of mercury). The weight under which particles might be taken care of is about 10-5 to 10-8 torr (not as much as a billionth of an air). Each of the three undertakings recorded above might be proficient in various ways. In one normal strategy, ionization is affected by a high vitality light emission, and particle detachment is accomplished by quickening and centering the particles in a shaft, which is then bowed by an outside attractive field. The particles are then recognized electronically and the subsequent data is put away and broke down in a PC. A mass spectrometer working in this mold is illustrated in the accompanying graph. The core of the spectrometer is the particle source. Here atoms of the specimen (dark spots) are barraged by electrons (light blue lines) issuing from a warmed fiber. This is called an EI (electron-affect) source. Gasses and unstable fluid specimens are permitted to spill into the particle source from a repository (as appeared). Non-unstable solids and fluids might be presented specifically. Cations shaped by the electron assault (red specks) are driven away by a charged repeller plate (anions are pulled in to it), and quickened toward different cathodes, having openings through which the particles go as a shaft. Some of these particles piece into littler cations and nonpartisan sections. An opposite attractive field avoids the particle bar in a circular segment whose range is contrarily relative to the mass of every particle. Lighter particles are avoided more than heavier particles. By shifting the quality of the attractive field, particles of various mass can be centered continuously around a locator settled toward the finish of a bended tube (additionally under a high vacuum).

Past Conference Report

Mass Spectrometry 2017

Mass Spectrometry 2017 Report:

We gratefully thank all our wonderful Keynote and Plenary Speakers, Conference Attendees, Students, Media Partners and Associations for making Mass Spectrometry 2016 grand success.

The 5^th International Conference on Current Trends in Mass Spectrometry, hosted by the ConferenceSeries LLC Ltd was held during September 25-26, 2017 at Holiday Inn, Atlanta, USA based on the theme “Recent scientific innovatory approaches, novel technologies and applications of Mass Spectrometry and Chromatography". Benevolent response and active participation was received from the Organizing Committee Members along with Scientists, Researchers, Students and leaders from the area of Mass Spectrometry, Chromatography and Analytical science, who made this event a grand success.

ConferenceSeries LLC Ltd expresses its gratitude to the conference Moderator, namely Dr. Jayaraman Shobini for taking up the responsibility to coordinate during the sessions. We are indebted to your support. Similarly we also extend our appreciation towards our Poster judges namely, Dr. Makhapa Makhafola, MINTEK, South Africa and Dr. Eduard Rogatsky, Wadsworth Center, USA.

ConferenceSeries LLC Ltd would like to convey a warm gratitude to all the Honorable guests and Keynote Speakers of Mass Spectrometry 2016:

Eduard Rogatsky, Wadsworth Center, USA

Dominic M. Desiderio, University of Tennessee Health Science Center, USA

Magnus S Magnusson, University of Iceland, Iceland

Mostafa el Sayed, Georgia Institute of Technology, USA

Rhongu wu, Georgia Institute of Technology, USA

Pao-Chi Liao, National Cheng-Kung University, Taiwan

Makhapa Makhafola, Research & Development, Mintek, South Africa

ConferenceSeries Ltd offers its heartfelt appreciation to organizations such as our esteemed Media Partners and other eminent personalities who supported the conference by promoting in various modes online and offline which helped the conference reach every nook and corner of the globe. It also took privilege to felicitate the Keynote Speakers, Organizing Committee Members, Chairs and Co-chairs who supported this event.

Best Poster Awards Winners:

• Daniel Milan, Mercer  University, USA

With the grand success of  Mass Spectrometry 2017, ConferenceSeries LLC Ltd is proud to announce the "8^th International Conference on Current Trends in Mass Spectrometry" to be held during October 31-November 01, 2018 at Columbus, USA.

Let us meet again @ Mass Spectrometry 2018

 

 

Past Reports  Gallery