Mehran F. Moghaddam
Celgene Corporation, USA
Title: Utility of Mass Spectrometry in Drug metabolism and pharmacokinetics (DMPK): Discovery of Small Molecule Drugs
Biography
Biography: Mehran F. Moghaddam
Abstract
In modern drug discovery, mass spectrometry (MS) plays a central role in determination of drug-like properties of small molecules. In an effort to manage compound attrition and to improve the odds of discovering viable development candidates, medicinal chemistry departments have increased their productivity and produce an ever increasing number of compounds. Most compounds are evaluated in a battery of in vitro and in vivo assays in drug metabolism and pharmacokinetics (DMPK) departments. These are labor intensive and time consuming assays and almost always utilize qualitative or quantitative mass spectrometric methods. DMPK groups have to mirror the increased productivity exhibited by the medicinal chemistry to prevent bottlenecks. In addition to assembling a highly qualified team and automation, a DMPK department must be creative in the use of its resources and the utility of MS in order to enabled generation of high quality data in an efficient, timely, and cost effective manner. Qualitative and quantitative MS approaches and their specific utility in discovery DMPK will be discussed in this presentation.