Current Trends in Mass Spectrometry

Biography

Biography: Yuri E. Moskalenko

Abstract

Slow volume fluctuations inside cranium have known since the middle of XIX Century. Although during passed time relations of their amplitude and frequency with some important physiological indices (pCO2, pO2 in brain tissue, functional activity of some brain structures, neurosurgical stages of brain activation) have been established, that these fluctuation couldn’t use in practice due to impossibility of their objective evaluation. Recently, spectrum analysis was applied for the study of intracranial slow volume fluctuations, recorded by coupling of noninvasive methods - multifrequency rheoencephalography and transcranial dopplerography with healthy volunteers and neurological patients. Spectrum analysis of 3 min fragments of recordings, provided by “Chart 5” software with quantitation 128 kHz, have shown, that frequency ranges 0.01 – 0,3 Hz include majority of spectral peaks, reflecting intracranial slow volume fluctuations and include also a few peaks, connected with of arterial pressure fluctuations and respiration. Comparison frequencies and amplitudes of spectral peaks, reflected intracranial volume fluctuations, show, that they are characterized by hemispheric asymmetry and by difference in surface and deep brain structures. Spectrograms, taken with patients, demonstrate increased number of peaks and decreased of their amplitude. After treatment, together, with disappearing of pathogenic symptoms, spectrograms are normalized. Received data indicate, that spectrum of intracranial slow volume fluctuations reflect the systems integration, (brain blood and CSF circulation as well skull mechanics) responsible for brain circulatory-metabolic supply. It is possibly to conclude, that spectral analysis of intracranial slow volume fluctuations, demonstrate quality of system integration in mechanism, which responsible for nutrition support of brain functioning.