Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 4th World Congress on Mass Spectrometry London, UK.

Day 2 :

Keynote Forum

Athula Attygalle

Center for Mass Spectrometry, Stevens Institute of Technology, USA

Keynote: Where is the charge located in multifunctional gaseous ions? A survey by Ion Mobility Mass Spectrometry

Time : 08:30- 08:55

Conference Series Euro Mass Spectrometry 2017 International Conference Keynote Speaker Athula Attygalle photo
Biography:

Athula Attygalle is a reaech professor at Stevens Institute of Technology, USA. After an international scientific safari (University of Ceylon, University of Sri Lanka, Tokyo Institute of Technology, University of Keele, University of Erlangen-Nürnberg, and University of Houston), Attygalle became the Director of the mass spectrometry facility of Cornell University in 1991, After 12 years at Cornell, Attygalle became a Professor at Stevens Institute of Technology in Hoboken, NJ, in 2001. He has published over 200 papers in reputed journals and holds five U.S. patents.

Abstract:

 The preferred charge sites of protonated or deprotonated molecules in the gas phase has been a topic of extensive research. In fact, the exact location of the initial charge site of the precursor ion is requisite that should be addressed before any pragmatic interpretation of a fragmentation spectrum is attempted.  Although the challenge appears seemingly simple, in reality it is not at all a trivial problem. One often assumes that the charge location can be easily predicted by knowing the gas-phase acidity or basicity of various groups present in a polyfunctional molecule.  However, in reality this a very challenging problem because generalizations valid for solution-based chemistry cannot be extended directly to gas-phase phenomena.  For example, there is sufficient experimental evidence to demonstrate that deprotonated p-hydroxybenzoic acid exists in gas phase as a mixture of carboxylate and phenoxide forms.  Analogously, protonated aniline exists as mixture of nitrogen- or ring-protonated forms.  Ion-mobility mass spectrometry (IM-MS) provides a way to determine relative population ratios of protomers or deprotomers that coexist under mass spectrometric ion generation conditions.  Employing IM-MS separation, we demonstrate that mass spectrometric source conditions used for gas-phase ion generation play an important role on the relative ratios of isomeric protomers and deprotomers that coexist under a specific set of experimental conditions.

Keynote Forum

Eduard Rogatsky

Wadsworth Center, USA

Keynote: Root causes of LC/MS data variability

Time : 08:55- 09:20

Conference Series Euro Mass Spectrometry 2017 International Conference Keynote Speaker Eduard Rogatsky photo
Biography:

Prof. Rogatsky serves as the Editor-in-Chief for the Journal of Chromatography and Separation Techniques (OMICS publishing group). During the last 10 years (from 2005) he has published over 30 scientific papers in per-reviewed journals (mostly as the first author) and has presented over 50 posters and lectures. Overall, he has made more than a hundred scientific presentations and publications. Eduard completed his M.Sc. in physical chemistry at Belarus State University (former USSR) in 1990. He completed his PhD in bioanalytical chemistry (Bar-Ilan University, Israel) in 1998. At the end of 1999, he started his post-doctorate at Albert Einstein College of Medicine and became a faculty member since 2001 and was a mass spectrometry director at the Biomarker Analytical Resource Core. From October 2015 Dr. Rogatsky is a supervisor of the Chemical Threat Laboratory in the Division of Environmental Health Sciences at Wadsworth Center, Albany NY, USA and continue to be an Adjunct Professor at Albert Einstein College of Medicine.

Abstract:

In a past decade in a literature were addressed different methodological questions, related to data variability between immunoassays and LC/MS methods (during clinical assay standardizations studies). However, reasons of inter-lab proficiency testing variability, performed only on LC/MS instruments typically are not discussed. While a pipetations inaccuracy limit is typically within 3% interval, reported proficiency testing results produced by well validated LC/MS methods, could be exceeding 20% bias or ± 3S consensus interval, even if the same method and same instrument brand were used in other laboratories. I present case studies demonstrating impact of calibration curve design, instrument settings, LC and MS instrumental conditions and analyte source chemistry on test results of specimens, blanks and quality controls.

Keynote Forum

Jianmin Chen

Fudan University, China

Keynote: Tropospheric multiphase chemistry elevated by diverse mass-spectrometric techniques

Time : 09:20- 09:45

Conference Series Euro Mass Spectrometry 2017 International Conference Keynote Speaker Jianmin Chen photo
Biography:

Jianmin Chen has completed his PhD at the age of 29 years from Fudan University. He is an atmospheric Scientist, distinguished professor and directors of Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, and International Collaboration Base of Climate and Environment (Ministry of Science and Technology of China) at Fudan University. He was a visiting associate professor at University of Pittsburgh from 1996 to 1997, and regularly visiting scientist in Institut de Combustion Aérothermique, Réactivité et Environnement-CNRS. He has published more than 180 pre-reviewed papers in geoscience and chemistry journals such as Chem. Rev., J. Amer. Chem. Soc., Atmos. Chem. Phys., Environ Sci. Technol. and J. Geophy. Res., and serving as an associated editor of Sci. Total Environ., and board members of Aerosol Air Qual. Res., J. Environ. Sci.  and Adv. Environ. Res.. He was honored as de chevalier dans l'ordre des palmes académiques, and the Enjoyment of the State Council of China special allowance in 2015. 

Abstract:

Recently, multifarious mass-spectrometric techniques (MAF) have been rapidly developed and applied to tropospheric multiphase chemistry. They play an important role in the studies of secondary aerosol formation, chemical components, atmospheric oxidation, haze episodes and cloud condensation nuclei (CCN), which impact many aspects of air quality, health and global climate. Here, a variety of MST is introduced to investigate multiphase chemistry in ambient air and laboratory studies, (i) secondary organic aerosols (SOA) formation was investigated by single particle ToF mass spectrometry from α-pinene–ozone system with seed aerosols in an aerosol chamber; (ii) particulate nitrate formation was firstly explored by aerosol ToF mass spectrometry. High molecular weight species were observed in urban Shanghai aerosols; (iii) desorption electrospray ionization mass spectrometry has been applied for the first time to the analysis of SVOCs in atmospheric aerosols and only a 1 µL droplet sample is needed for analysis without or with little pretreatment; (vi) UHPLC coupled with Orbitrap MS was used in PM2.5 analysis. About 200 formulas of organosulfates, were found including dozens of formulas of nitrooxy- organosulfates with various numbers of isomers. It is increasing interest in MST combined with hygroscopic and optical techniques to explore atmospheric process and radiative forcing. 

Conference Series Euro Mass Spectrometry 2017 International Conference Keynote Speaker Ali Mohammad-Djafari photo
Biography:

Ali Mohammad-Djafari received the B.Sc. degree in electrical engineering from Polytechnic of Teheran, in 1975, the diploma degree (M.Sc.) from Ecole Supérieure d'Electricit(SUPELEC), Gif sur Yvette, France, in 1977, the "Docteur-Ingénieur" (Ph.D.) degree and "Doctorat d'Etat" in Physics, from the University of Paris Sud 11 (UPS), Orsay, France, respectively in 1981 and 1987.He was Assistant Professor at UPS for two years (1981-1983). Since 1984, he has a permanent position at "Centre national de la recherche scientifique (CNRS)" and works at "Laboratoire des signaux et systèmes (L2S)" at Centrale-Supélec. He was a visiting Associate Professor at University of Notre Dame, Indiana, USA during 1997-1998. From 1998 to 2002, he has been at the head of Signal and Image Processing division at this laboratory. 

Abstract:

There have been recent advances in different techniques of Mass spectrometry. However, in many of these techniques there are common mathematical framework: Inverse problems. In this work, a few of these inverse problems are presented and an overview of the methods to handle them is given.  The Bayesian inference approach is a very useful approach to handle these problems as it give the possibility to account both for prior modeling of the signals and images and for the uncertainly associated to the measurement process. It also gives the necessary tools to estimate the hyper parameters and the remaining uncertainties in the proposed solution. To illustrate this, we take the deconvolution problem which is one of the main inverse problems in mass spectrometry and go through the different regularization and Bayesian inference methods and compare their relative performances.