Satish.C.Puri
CSIR, India
Title: Tryst with anticancer drug design -application of LC/ESI-MS/MS spectrometry of anticancer metaabolites from novel fungal endophytes
Biography
Biography: Satish.C.Puri
Abstract
Chemical revolution started in the last century by recognition of chemical structure and development of method of isolation, characterization. Modern chemistry lays more emphasis on material biological environments health and medicines. Environmental concerns have forces chemist to search remedies for imperiled planet. The application oriented modern scientific endeavors are not a single scientific disciplines, therefore promoting multidisciplinary resources and emphasizing sustainability shall be a root of any chemical design. Drug discovery is one of such frontiers area which is originated in chemical sciences but feed on numbers of disciplines for accomplishing any design. Despite advancement in modern scientific methodologies and computer assisted de-Nova drug designing, continue to be mainstay of discovery of new leads for drug designing. Presentation enlists program modern target for anticancer drug program includes examples from our work of some cytotoxic biomolecules with emphasis on environmentally benign protocols and natural products in conventional chemotherapy regimen. Calling of visionaries, game changers and paradigm shifters in biochemical ready to take the world most challenging diseases needs and quest for cures are committed to begin the world research-intensive biopharmaceuticals for advance cancer.A plethora of natural products represent an invaluable gold mine of pharmacophores. Fungal endophyte is a diverse class microorganism that colonizes plant without any symptoms of disease. Fungal endophytes display a broadspectrum of biological activities viz; tubulin, topoisomerase, angiogenesis inhibitors, immunomodulators, radio-protectors and antioxidants etc. Endophytes proficiency has inspired us to detection and characterization of biometabolites like taxoids, podophyllotoxins, camptothecinoids, combretstatins, epofornin phialmusltin, ramlosin and diaploic acid from microbes using LC/ESI-MS/MS (Tandem) spectrometry in low levels of detectable of anticancer bimolecular in last decade.