Josef Havel
Masaryk University, Czech Republic
Title: MS for characterization and analysis of inorganic and nano materials - mass spectrometer as a kind of synthesizer
Biography
Biography: Josef Havel
Abstract
Mass spectrometry (MS) is one of the most important techniques to fulfil demand for chemical/structural information frombiological systems. Structural analysis of organic compounds, biomolecules, etc. iswell known and widely used. Inorganic materials extensively penetrate to medicine as drugs, nano-carriers for drug delivery and also to MS as matrices (nano-gold, nano-diamonds) or as SALDI (Surface Assisted Laser Desorption Ionisation) or SELDI (Surface Enhanced LDI) matrices - to
enhance ionisation. However, MS of inorganic materials requires different approach: (i) mostly, usual MALDI matrices cannotbe used,
(ii) instead of MALDI just LDI is to be applied
(iii) fragmentation of materials (mostly unknown) accompanies LDI
and should be taken into account
(iv) interaction of the ions in plasma plume should be taken into consideration. In spite of
the problems it is demonstrated that MS can be applied for characterization/analysis of inorganic materials:
(a) nano-clusters
(or graphene oxide, etc.) can increase ionisation of biomolecules in MALDI
(b) in situ generated nano-clusters of monoisotopic
elements can be used as internal/external calibration standards
(c) structures of amorphous chalcogenides (atomic
switch memory Ge2Sb2Te5 thin films; As2Ch3S3 chalcogenides; As-S-Se or AgAsS2 glasses; complex glasses (GeSe2)(100-x)
(Sb2Se3)(x), etc. can be elucidated or determined (d) MS can be used for laser ablation synthesis (carbides, selenides, etc.) of
novel compounds. Concluding, even if the fragmentation accompanying often MS of inorganics is not completely known, MS is useful for materials analysis and in addition the instrumentation can be as a kind of a synthesizer applied for generation of new compounds.