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7th World Congress on Mass Spectrometry

Rome, Italy

Yuliya E Silina

Yuliya E Silina

INM-Leibniz Institute for New Materials, German

Title: Organic and inorganic mass spectrometry as a helpful tool for bio-andenvironmental sensors design optimization


Biography: Yuliya E Silina


Time-of-flight secondary ion mass spectrometry (TOF-SIMS) has been proven as a powerful tool for detailed informationon polymer composition due to its high sensitivity, high dynamic range, specificity and selectivity. TOF-SIMS can provide information about oligomer distributions, average molecular weights, fingerprint patterns for polymer identification,monomeric unit sequences, branching, cross-linking substitution, copolymer structures and additives or impurities. However,major challenges, viz. distinguish the surface from the rest of thematerial,unresolvable isobaric interferences regardless ofthe geometry of high-resolution instruments still remain unsolved. Herein, we will introduce an alternativestrategy utilizingliquid chromatography-electrospray ionization-tandem mass spectrometry (Q-TOF LC-MS), head space gas chromatography(HS-GC-MS) and high resolution inductively coupled plasma mass spectrometry (HR-ICP-MS) to study the polymer stability and degradation mechanisms. The examples discussed will provide an overview of using HR-ICP-MS and Q-TOF LC-MS to glucose biosensor design optimization, viz. multi-layer biosensor stability and to identify critical system parameters that affect the biosensor response. In addition, we will demonstrate how HS-GC-MS technique might be used to set an optimal bulk poly(dimethylsiloxane) (PDMS) sensor inluding thickness and cross-linking ratio as well as sampling/loading approaches aiming an application to fragrance controlled release maintained the constant ratio of volatile compounds. We believe, thereported strategy, will allow mapping the influence of the complete set of system input parameters on the sensor response, which subsequently opens up the possibilities for optimization of the design of sensors and their performance.