Jianke Li
Chinese Academy of Agricultural Science, China
Title: Proteomics reveals the molecular underpinnings of stronger learning and memory in eastern compared to western bees
Biography
Biography: Jianke Li
Abstract
The characterized and compared the proteomes of mushroom bodies (MBs), antennal lobes (ALs) and optical lobes (OLs) in the brain of both species, and biologically validated the functions related to learning and memory. Acc and Aml have evolved similar proteome signatures in MBs and OLs to drive the domain-specific neural activities. In MBs of both species, commonly enriched and enhanced functional groups related to protein metabolism and Ca2+ transport relative to ALs and OLs, suggests that proteins and Ca2+ are vital for consolidatin g learnin g and me ory via modulati n of s nap tic struc ture an d signal tra nsduction. F urthe more, in O L sof both specie ,the main ly enriche d ribonucleosid metabo lis sugge ts its vita l role as secon d messenger i npromoting ph oto transd uction. Nota bly , in A sof both s pec es,distinct pr oteo me setting hav e shaped to p rim e olfactor y learni g and me ory. In AL of Acc this i s sup ported by the enr iched c yto kel ton or gan zati n to susta i nol actory signal ng through modu lation of pl asticity i ng lomeruli a nd in tracellu lar t rans port In AL of Aml, h owever, t he enriche d functional gro ups i pli ate d in hydrog e nio n transport are in dicativ e of their impo rta nce i su pport ing olfact ory proces ses by regu lati n of synap tic transmis sion. The biologic al c nfirmati n of enhance d act iviti sof protei metaboli s ma nd si nal trans duction in A Lsan d MBs of Acc rela tive t o in A ml demo nstr tes that a stron ger sense o f olf ctory l arn ng and memor y ha s evolved i Acc. The rep orte d first in depth proteome data of honeybe e br in s ub- organ s provide a nove l insigh t into the m olecular basis of neurobiolog y, and is po tent ially u seful for further neurologic al s tudies in ho neybees and other inse cts.