Zhang QI is a major player of the research team in university project, she has been responsible for coordinating with members at the center of structure biology at Indiana University and Tulane University on solving the crystal structure of the MDM2/ribosomal protein complex. She has been developing an elegant and sophisticated multigene expression system to co-express and co-purify the novel protein complex in order to explore the structures and functions of the p53 regulators MDM2 and the ribosomal proteins. She has obtained extensive experience in the screening for therapeutic candidates and the biochemical characterization of drug targets as a postdoctoral researcher at Indiana University School of Medicine. Dr Zhang collaborated efficiently with scientists from various areas, such as molecular biology, cellular biology, biochemistry, computer-aided drug design, combinatorial chemistry, clinical pharmacology, drug analysis and high-throughput screening, facilitating the progression of drug discovery projects. Her research will be complementary to the mission of Tulane School of Medicine and Tulane Cancer Center in discovering cures for cancer diseases and building the essential bridge between basic research and clinical research to accomplish this objective.
Targeting the p53-pathway for the treatment of cancer; Study of p53 regulators by a combination of biochemical and structural analyses.