Recent Advances and Developments

Along with hyphenated technologies such as (LC-MS) as well as (GC-MS), MS facilitates the establishment and advancement of high-throughput, qualitative and quantitative analytical methods used for drug discovery. In order to advances in LC and MS have enabled more efficient peak separation of complex mixtures employing multi – dimensional LC (2DLC) and more precise, improved resolution and ion mobility partition by MS. A selection of advanced LC-MS technologies applied to drug discovery chemistry, comprising compound ionization hyphenated systems, multidimensional systems, ion mobility spectrometry and HRMS for quantitative analysis and impurity detection.

  • Advances in sample preparation and MS Interface design
  • Cs-SIMS, MeV-SIMS, FIB-SIMS and In-situ liquid SIMS
  • TIMS and SSMS
  • MALDI-TOF, SELDI-TOF and TOF-SIMS
  • ICP-MS and IRMS
  • Accelerator Mass Spectrometry
  • Triple Quadrupole GC-MS/LC-MS, next evolution
  • Advanced Separation Technique UHPLC, NANO-UHPLC, HIC, Capillary Electrophoresis
  • New Ionization Techniques such as DESI, DART, ASAP and Pitfalls
  • Developments in Mass Analyzers Quadrupoles, Linear Ion Traps, FTMS, TOF (TIMEOF FLIGHT), Orbit traps
  • Imaging and Profiling with Mass Spectrometry MALDI Technique and Applications
  • High Resolution of Mass Spectrometry Types and Merits

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