Biography
Zhang QI is a major player of the research team in university project, she has been responsible for coordinating with members at the center of structure biology at Indiana University and Tulane University on solving the crystal structure of the MDM2/ribosomal protein complex. She has been developing an elegant and sophisticated multigene expression system to co-express and co-purify the novel protein complex in order to explore the structures and functions of the p53 regulators MDM2 and the ribosomal proteins. She has obtained extensive experience in the screening for therapeutic candidates and the biochemical characterization of drug targets as a postdoctoral researcher at Indiana University School of Medicine. Dr Zhang collaborated efficiently with scientists from various areas, such as molecular biology, cellular biology, biochemistry, computer-aided drug design, combinatorial chemistry, clinical pharmacology, drug analysis and high-throughput screening, facilitating the progression of drug discovery projects. Her research will be complementary to the mission of Tulane School of Medicine and Tulane Cancer Center in discovering cures for cancer diseases and building the essential bridge between basic research and clinical research to accomplish this objective.
Research Interest
Targeting the p53-pathway for the treatment of cancer; Study of p53 regulators by a combination of biochemical and structural analyses.
Biography
Dr. Campagna completed his B.S. in Chemistry at North Carolina State University in 2000 and conducted research with Prof. Jonathan S. Lindsey on the chemical synthesis of bacterial chromosomes. He received his Ph.D. from Princeton University in 2006, after working with Prof. Martin F. Semmelhack on a joint project with Profs. Bonnie L. Bassler and Frederick M. Hughson to characterize the chemical properties of an inter-species bacterial signaling molecule, autoinducer-2. Dr. Campagna then performed post-doctoral fellow research with Prof. Joshua D. Rabinowitz at the Lewis-Sigler Institute for Integrative Genomics at Princeton University where he developed mass spectrometric methods for the identification of novel biochemical pathways and natural products from whole cell extracts. He joined the Chemistry Department at UT Knoxville in August 2007.
Research Interest
organic synthesis, combinatorial methods, and analytical techniques, such as tandem liquid chromatography-mass spectrometry and nuclear magnetic resonance, to answer biologically relevant questions at the molecular level.
Biography
Research Interest
Protein folding, aggregation, complexes; proteomics, mass spectrometry of non-covalent interactions.